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Home - Products - MAPK/ERK Signaling - Ras - NSC 23766 trihydrochloride

NSC 23766 trihydrochloride

CAS No. 1177865-17-6

NSC 23766 trihydrochloride( NSC-23766 trihydrochloride;NSC23766 trihydrochloride )

Catalog No. M10603 CAS No. 1177865-17-6

A specific small molecule inhibitor of Rac GTPase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NSC 23766 trihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A specific small molecule inhibitor of Rac GTPase.
  • Description
    A specific small molecule inhibitor of Rac GTPase; potently blockes serum or PDGF-induced Rac1 activation and lamellipodia formation without affecting the activity of endogenous Cdc42 or RhoA; inhibits the proliferation, anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.
  • Synonyms
    NSC-23766 trihydrochloride;NSC23766 trihydrochloride
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    RacGTPase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1177865-17-6
  • Formula Weight
    530.96
  • Molecular Formula
    C24H38Cl3N7
  • Purity
    >98% (HPLC)
  • Solubility
    H2O: ≥ 32 mg/mL; DMSO: 7.6 mg/mL
  • SMILES
    Cl.Cl.Cl.CCN(CC)CCCC(C)NC1=NC(C)=CC(NC2=CC3=C(N)C=C(C)N=C3C=C2)=N1 |c:14,20,26,29,31,t:11,18,23|
  • Chemical Name
    4,6-Quinolinediamine, N6-[2-[[4-(diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-, trihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gao Y, et al. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7618-23.
2. Barros P, et al. Mol Cell Biol. 2009 Aug;29(15):4156-66.
3. Yoshida T, et al. Mol Cancer Ther. 2010 Jun;9(6):1657-68.
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